Killing Floor 1.008' title='Killing Floor 1.008' />Issuu is a digital publishing platform that makes it simple to publish magazines, catalogs, newspapers, books, and more online.Easily share your publications and get.Why Natural Thyroid is Better than Synthroid Part Two.Why Natural Thyroid is Better than Synthroid, Part Two.This article is part two of a series.For Part One, Click Here.Will Thyroid Medication Give Me Osteoporosis New concerns were raised by Marci Turner in the April 2.British Medical Journal reporting elderly women on Synthroidtm have increased fracture risk.Note Synthroid is a T4 only medication, also called thyroxine or levothyroxine.A previous 2. 01.Murphy looked at thyroid function and fracture risk in normal postmenopausal women, and they found a 3.TSH values TSHthyroid stimulating hormone.Higher TSH was protective of fracture.No Real Consensus on The Issue.To add confusion, a 2.Schneiderreviewed 6.T4 only on bone mineral density, finding no real concensus and concluding that, currently debate still exists about the effects of thyroid hormone therapy on skeletal integrity, that is the safety of levothyroxine use with respect to bone mineral density.Lets take a look at this issue and try to come up with some real answers.The Calcitonin Connection.The thyroid gland not only makes thyroid hormone.It also makes Calcitonin, a hormone manufactured by the parafollicular calls C cells in the thyroid tissue.Calcitonin is involved in calcium metabolism, bone maintenance and prevents osteoporosis.Left image Calcitonin courtesy of wikimedia commons.Thyroid disorders cause destruction of calcitonin cells Hashimotos thyroiditis is a common cause of hypothyroidism and is associated with destruction of the C cells and loss of calcitonin production.The resulting Calcitonin deficiency is a potential cause of bone resorption and osteoporosis.On the other hand, treatment with calcitonin nasal spray is an FDA approved treatment for osteoporosis and is shown to increase bone density.Hashimotos, radio iodine and surgery all destroy Calcitonin Cells.The autoimmune process of Hashimotos, thyroid ablation with radioactive iodine andor surgery all reduce or eliminate thyroid function, and the C cells which make calcitonin get knocked out as well.Synthroid, levothyroxine, and T4 only medications do not provide the missing calcitonin.One would expect the calcitonin deficient patient to be at greater risk for osteoporosis and fracture.Unlike Synthroid and T4 only medications which DO NOT contain calcitonin, natural desiccated thyroid DOES CONTAIN calcitonin, providing the missing hormone, and is the preferred form of thyroid medication.None of the Studies Used Natural Desiccated Thyroid.Unfortunately. all of the medical studies that examined the bone thyroid connection used T4 only medication, none used desiccated natural thyroid, so we dont have a good comparison study to evaluate the long term lack of osteoporosis from natural desiccated thyroid.A good use of NIH research funding would be comparing the bone density and long term risk of fracture with natural desiccated thyroid compared to T4 only medications.Dont hold your breathe.The NIH is a government agency, and the government is influenced by Big Pharma dollars, so natural is out and synthetic is in.We may never see NIH funding for natural desiccated thyroid.Above Left image chemical structure of thyroxine, T4 courtesy of wikimedia commons.The TSH Connection.TSH is Protective and Prevents Bone Resorption.Advances in our understanding of physiology and animal research have revealed TSH hormone thyroid stimulating hormone has a direct effect on bone cells, preventing degradation of bone and bone resorption, and therefore protective of bone density.This could explain the many studies that find a correlation between higher TSH and improved bone density.The problem with using TSH as a treatment for osteoporosis is that higher TSH is associated with increased heart disease see the HUNT study, as well as a host of low thyroid symptoms of fatigue, malaise, muscle aches and pains etc.Patients feel better with a lower TSH and higher thyroid function, so cutting back on thyroid medication to let the TSH drift up may be good for bone density, but it is not good for the patient.Good News About Bioidentical Hormones.The good news is that the TSH effect on bone density is relatively modest and is offset by the addition of estrogen, a bioidentical hormone, which increases bone density.In addition, we routinely employ a natural bone building program to optimize vitamin D levels which protects and maintains bone density.In conclusion, an excellent reason to switch from T4 only thyroid medication to natural desiccated thyroid is because it contains Calcitonin, protective of bone density and preventive of osteoporosis.T4 only medication does not contain calcitonin and is associated with loss of bone density and increased fracture risk.We have found good clinical results with a natural dessicated thyroid product called Naturethroid from RLC labs.Dosage range is from one to four Grains per day depending on underlying thyroid function and body weight.Atricles with Related Interest This is Part Two of the article.For Part One of this article, click here.Selenium and Thyroid More Good News.New Study shows Natural Thyroid Better than Synthroid.Why Natural Thyroid is Better than Synthetic Part One.Why Natural Thyroid is Better Part Two.The TSH Reference Range Wars Part One TSH Wars, Part Two.Jeffrey Dach MD7.Griffin Road. Davie, Fl 3.Other Books Also Recommended Hypothyroidism the Unsuspected Illness, by Broda Barnes MDIodine, Why You Need It and Why You Cant Live Without It by David Brownstein MDHypothyroidism, Type Two by Mark Starr MDAdrenal Fatigue The 2.Century Stress Syndrome by Wilsonjeffrey dach md.Links and Refernences1 http www.J Clin Endocrinol Metab.Jul 9. 57 3. 17. Epub 2.Apr 2. Thyroid function within the upper normal range is associated with reduced bone mineral density and an increased risk of nonvertebral fractures in healthy euthyroid postmenopausal women.Murphy E, Gler CC, Reid DM, Felsenberg D, Roux C, Eastell R, Williams GR.Molecular Endocrinology Group, 7th Floor Commonwealth Building, Hammersmith Hospital, Du Cane Road, London W1.NN, United Kingdom.CONTEXT The relationship between thyroid function and bone mineral density BMD is controversial.Existing studies are conflicting and confounded by differences in study design, small patient numbers, and sparse prospective data.OBJECTIVE We hypothesized that variation across the normal range of thyroid status in healthy postmenopausal women is associated with differences in BMD and fracture susceptibility.DESIGN The Osteoporosis and Ultrasound Study OPUS is a 6 yr prospective study of fracture related factors.SETTING We studied a population based cohort from five European cities.PARTICIPANTS A total of 2.Subjects with thyroid disease and nonthyroidal illness and those receiving drugs affecting thyroid status or bone metabolism were excluded, leaving a study population of 1.INTERVENTIONS There were no interventions.MAIN OUTCOME MEASURES We measured free T4 f.T4 picomolesliter, free T3 f.T3 picomolesliter, TSH milliunitsliter, bone turnover markers, BMD, and vertebral, hip, and nonvertebral fractures.RESULTS Higher f.T4 beta 0. 0. P 0.T3 beta 0. 0. P 0.BMD at the hip, and higher f.T4 was associated with increasing bone loss at the hip beta 0.P 0. 0. 15. After adjustment for age, body mass index, and BMD, the risk of nonvertebral fracture was increased by 2. My Utmost For His Highest Audio . P 0. 0. 02 and 3.P 0. 0. 06 in women with higher f.T4 or f. T3, respectively, whereas higher TSH was protective and the risk was reduced by 3.P 0. 0. 28. There were independent associations between f.T3 and pulse rate beta 0.P 0. 0. 06, increased grip strength beta 0.Plt 0. 0. 01, and better balance beta 0.P lt 0. 0. 01, indicating that the relationship between thyroid status and fracture risk is complex.CONCLUSIONS Physiological variation in normal thyroid status is related to BMD and nonvertebral fracture.Hashimotos destroys the C cells calcitonin cells2 http www.Thyroid. 1. 99. 8 Jun 86 5.Quantitative analysis of C cells in Hashimotos thyroiditis.Lima MA, Santos BM, Borges MF.Brazil. The objective of the present investigation was to study quantitatively C cells in Hashimotos thyroiditis HT by analyzing 2.
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